Cu (II) GTSM

Cu (II) GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu (II) GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu (II) GTSM also decreases the abundance of Amyloid-β trimers. Cu (II) GTSM is a potential anticancer and antimicrobial agent[1][2].

Product Specifications

CAS Number

[68341-14-0]

UNSPSC

12352100

Target

Amyloid-β; GSK-3

Type

Reference compound

Related Pathways

Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/cu-ii-gtsm.html

Purity

95.0

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCL; heat to 60°C)

Smiles

CNC1=N[N]2=CC=[N]3N=C(NC)[S-][Cu+2]23[S-]1

Molecular Formula

C6H10CuN6S2

Molecular Weight

293.86

References & Citations

[1]Andres SA, et al. Synthesis, Characterization, and Biological Activity of Hybrid Thiosemicarbazone-Alkylthiocarbamate Metal Complexes. Inorg Chem. 2020;59 (7) :4924-4935.|[2]Crouch PJ, et al. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proc Natl Acad Sci U S A. 2009;106 (2) :381-386.