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Pomalidomide-PEG1-NH2 (hydrochloride)

Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand[1].

Product Specifications

CAS Number

[2380273-67-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pomalidomide-peg1-nh2-1-hydrochloride.html

Purity

97.05

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

[H]Cl.NCCOCC(NC1=CC=CC(C2=O)=C1C(N2C(C3=O)CCC(N3)=O)=O)=O

Molecular Formula

C17H19ClN4O6

Molecular Weight

410.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee B, et al. Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :51-66.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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