(S, R, S) -AHPC-O-Ph-PEG1-NH2
(S, R, S) -AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S, R, S) -AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614) . PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02[1].
Product Specifications
CAS Number
[2361117-24-8]
Product Name Alternative
VH032-O-Ph-PEG1-NH2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-o-ph-peg1-nh2.html
Purity
96.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCOC1=CC=C(C=C1)OCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C=C3)C4=C(N=CS4)C)=O)=O)C(C)(C)C)=O
Molecular Formula
C32H41N5O6S
Molecular Weight
623.76
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456 (19) 30362-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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