SAHH Recombinant Rabbit Monoclonal Antibody [JE41-31]
AdoHcyase is encoded by the AHCY gene in humans, which is believed to have a prognostic role in neuroblastoma. AdoHcyase is significantly associated with adenosine deaminase deficiency, which classically manifests in severe combine immunodeficiency (SCID). Accumulated adenosine derivatives, dATPs, irreversibly bind to and inhibit AdoHcyase, promoting the buildup of S-adenosyl-L-homocystine (due to equilibrium constant favors S-adenosyl-L-homocystine), a potent inhibitor of methyl transfer reactions.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
AHCY, SAHH
Swiss Prot
P23526 Human, P50247 Mouse, P10760 Rat
Cellular Locus
Cytoplasm, Melanosome, Nucleus, Endoplasmic reticulum.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within
Isotype
IgG
Clone
JE41-31
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:200
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 48 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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