Difluprednate

Difluprednate is a glucocorticoid receptor (GC receptor) agonist with a Ki of 0.78 nM. Difluprednate's active metabolite 21-deacetylated difluprednate (DFB) is a competitive agonist of GC receptors with a Ki of 0.061 nM. Difluprednate binds to GC receptors through metabolism to DFB, regulating the transcription of inflammatory mediator genes, thereby exerting anti-inflammatory activity. Difluprednate can be used for research related to ocular inflammation, such as postoperative inflammation, anterior uveitis, etc[1][2].

Product Specifications

CAS Number

[23674-86-4]

UNSPSC

12352211

Hazard Statement

H315, H319, H335, H361

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Difluprednate.html

Concentration

10mM

Purity

99.64

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C([C@]([C@]12C)(CC[C@@]1([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C2)OC(CCC)=O)COC(C)=O

Molecular Formula

C27H34F2O7

Molecular Weight

508.55

Precautions

H315, H319, H335, H361

References & Citations

[1]Tajika T, et al. Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion. Xenobiotica. 2010 Aug;40 (8) :569-77.|[2]Tajika T, et al. Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay. J Ocul Pharmacol Ther. 2011 Feb;27 (1) :29-34.|[3]Mithal, et al. Difluprednate: an overview. Delhi Journal of Ophthalmology 23.3 (2013) : 165-168.