Felbamate

Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .

Product Specifications

CAS Number

[25451-15-4]

Product Name Alternative

W-554; ADD-03055

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/felbamate.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NC(OCC(C1=CC=CC=C1)COC(N)=O)=O

Molecular Formula

C11H14N2O4

Molecular Weight

238.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Kuo CC, et al. Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channels. Mol Pharmacol. 2004 Feb;65 (2) :370-80.|[2]Harty TP, et al. Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39 (1) :47-55.