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Pomstafib-2

Product Specifications

UNSPSC Description

Pomstafib-2 is a potent and selective STAT5b inhibitor. Pomstafib-2 decreases the expression of pSTAT5b and induces Apoptosis[1][2].

Target Antigen

Apoptosis; STAT

Type

Reference compound

Related Pathways

Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pomstafib-2.html

Purity

99.37

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)=C1)COC2=CC=C(C(NC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2

Molecular Weight

1101.03

References & Citations

[1]Elumalai N, et al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819.|[2]Gräb J, et al. The STAT5b Linker Domain Mediates the Selectivity of Catechol Bisphosphates for STAT5b over STAT5a. ACS Chem Biol. 2019 Apr 19;14(4):796-805.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-112649/Pomstafib-2-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-112649/Pomstafib-2-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2332841-83-3

Available Sizes

Curated Selection

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