Colletofragarone A2
Product Specifications
CAS Number
181377-06-0
UNSPSC Description
Colletofragarone A2 can be be isolated from the fungus Colletotrichum?sp. (13S020). Colletofragarone A2 inhibits mutant p53 and HSP90 with anti-cancer activity. Colletofragarone A2 promotes degradation and aggregation of mutant p53 and suppressing tumor growth in vivo[1].
Target Antigen
HSP; MDM-2/p53
Type
Natural Products
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/colletofragarone-a2.html
Solubility
10 mM in DMSO
Smiles
C/C=C/C=C/C=C/C1=C2[C@@]3([H])[C@@](C=CC([C@@]3([H])[C@H](O)C[C@H](O)C[C@H](C)OC2=O)=O)([H])O1
Molecular Weight
386.44
References & Citations
[1]Sadahiro Y, et al. Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53. Chem Res Toxicol. 2022 Aug 26.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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