Valproic acid (sodium)
Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[1][2][3][4][5][6][7].
Product Specifications
CAS Number
[1069-66-5]
Product Name Alternative
Sodium Valproate; VPA (sodium) ; 2-Propylpentanoic acid (sodium)
UNSPSC
12352211
Hazard Statement
H302, H361
Target
Apoptosis; Autophagy; Endogenous Metabolite; HDAC; HIV; Mitophagy; Notch; Organoid
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Valproic-acid-sodium-salt.html
Purity
99.65
Solubility
DMSO : 10 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C(CCC)CCC
Molecular Formula
C8H15NaO2
Molecular Weight
166.19
Precautions
H302, H361
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HDAC; HDAC1; HDAC2
Citation 01
Available Sizes
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