MK-8745
MK-8745 is an aurora A kinase inhibitor with an IC50 of 0.6 nM.
Product Specifications
CAS Number
885325-71-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Aurora Kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MK-8745.html
Concentration
10mM
Purity
99.08
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC=CC(Cl)=C1F)N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2
Molecular Formula
C20H19ClFN5OS
Molecular Weight
431.91
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jayasree S Nair et al. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent.|[2]Aparajita Chowdhury et al. A novel Aurora kinase A inhibitor MK-8745 predicts
 TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines.
 Leuk Lymphoma, 2012 Mar, 53 (3) :462-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A
Available Sizes
Frequently Asked Questions
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