What is the catalog number for ShK toxin?

The catalog number for ShK toxin is HY-P3071.

What sizes are available for ShK toxin?

ShK toxin is available in the following size(s): 1 Each.

Is ShK toxin in stock?

ShK toxin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures ShK toxin?

ShK toxin is manufactured by QuantiMol.

What is the estimated delivery time for ShK toxin?

Estimated delivery time for ShK toxin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for ShK toxin?

The safety data sheet for ShK toxin is available here: http://file.medchemexpress.com/batch_PDF/HY-P3071/.

ShK toxin

ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel) . ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus) . ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation[1][2].

Product Specifications

CAS Number

172450-46-3

Product Name Alternative

Stichodactyla helianthus neurotoxin

UNSPSC

12352209

Hazard Statement

H302-H312-H332

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/shk-toxin.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(O)=O)NC1=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H]3[C@H](O)C)=O)=O)=O)NC4=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@H]1[C@H](O)C)=O)=O)NC3=O)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H]4CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C169H274N54O48S7

Molecular Weight

4054.80

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Castañeda O, et al. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33 (5) :603-13.|[2]Beeton C, et al. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11;283 (2) :988-97.