ShK toxin

ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel) . ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus) . ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation[1][2].

Product Specifications

CAS Number

[172450-46-3]

Product Name Alternative

Stichodactyla helianthus neurotoxin

UNSPSC

12352209

Hazard Statement

H302-H312-H332

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/shk-toxin.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(O)=O)NC1=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H]3[C@H](O)C)=O)=O)=O)NC4=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@H]1[C@H](O)C)=O)=O)NC3=O)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H]4CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

Molecular Formula

C169H274N54O48S7

Molecular Weight

4054.80

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Castañeda O, et al. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33 (5) :603-13.|[2]Beeton C, et al. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11;283 (2) :988-97.