TTK/PLK1-IN-1
TTK/PLK1-IN-1 (Formula I) is the inhibitor for threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) with IC50 of 7 nM and 72 nM. TTK/PLK1-IN-1 regulates spindle assembly checkpoint (SAC), and exhibits antitumor efficacy against TNBC[1].
Product Specifications
CAS Number
1817791-70-0
UNSPSC
12352005
Target
Mps1; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ttk-plk1-in-1.html
Smiles
O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCNCC5)C=C4OC)N=C3N2C=C1)NC6=C(C)C=CC=C6C
Molecular Formula
C30H33N7O2
Molecular Weight
523.63
References & Citations
[1]Lane H, et al., Pharmaceutical combinations for use in the treatment of neoplastic diseases. WO2023167549.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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