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TTK/PLK1-IN-1

TTK/PLK1-IN-1 (Formula I) is the inhibitor for threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) with IC50 of 7 nM and 72 nM. TTK/PLK1-IN-1 regulates spindle assembly checkpoint (SAC), and exhibits antitumor efficacy against TNBC[1].

Product Specifications

CAS Number

1817791-70-0

UNSPSC

12352005

Target

Mps1; Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ttk-plk1-in-1.html

Smiles

O=C(C1=C2CCC3=CN=C(NC4=CC=C(N5CCNCC5)C=C4OC)N=C3N2C=C1)NC6=C(C)C=CC=C6C

Molecular Formula

C30H33N7O2

Molecular Weight

523.63

References & Citations

[1]Lane H, et al., Pharmaceutical combinations for use in the treatment of neoplastic diseases. WO2023167549.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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