GSK-LSD1 (dihydrochloride)
GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.
Product Specifications
CAS Number
[2102933-95-7]
UNSPSC
12352005
Target
Histone Demethylase; Monoamine Oxidase
Type
Reference compound
Related Pathways
Epigenetics; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK-LSD1_Dihydrochloride.html
Purity
99.45
Solubility
DMSO : ≥ 62.5 mg/mL
Smiles
C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1.Cl.Cl
Molecular Formula
C14H22Cl2N2
Molecular Weight
289.24
References & Citations
[1]Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215|[2]Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864 (12) :2428-2437.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1
Citation 01
Adv Mater. 2021 May;33 (18) :e2100949.|Bioorg Chem. 2024 Jul 1:150:107603.|bioRxiv. 2024 Aug 19:2024.08.17.607802.|Clin Exp Med. 2025 Nov 25;26 (1) :33.|Cytokine. 2022 Mar:151:155789.|Nat Commun. 2021 Dec 8;12 (1) :7142.|Nat Commun. 2025 Feb 1;16 (1) :1241.|Nat Commun. 2025 Jan 2;16 (1) :212.|Nature. 2025 Jun;642 (8067) :508-518.|Patent. US20180263995A1.|Signal Transduct Target Ther. 2022 Apr 13;7 (1) :102.|Res Sq. 2025 Apr 01.
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RC221626L4V 200 µL
FOXD4L6 (NM_001085476) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details