Zanapezil (free base)

Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM) . Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD) [1].

Product Specifications

CAS Number

[142852-50-4]

Product Name Alternative

TAK-147 (free base)

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zanapezil-free-base.html

Purity

99.23

Solubility

10 mM in DMSO|DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C2CCCCNC2=C1)CCC3CCN(CC4=CC=CC=C4)CC3

Molecular Formula

C25H32N2O

Molecular Weight

376.53

References & Citations

[1]K Hirai, et al. Neurochemical effects of 3-[1- (phenylmethyl) -4-piperidinyl]-1- (2,3,4,5-tetrahydro-1H-1-b enzazepin-8-yl) -1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, in rats. J Pharmacol Exp Ther. 1997 Mar;280 (3) :1261-9.|[2]Izzettin Hatip-Al-Khatib, et al. Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats. Brain Res. 2004 Jun 25;1012 (1-2) :169-76.