(R) -TTBK1-IN-1

(R) -TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R) -TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968) . (R) -TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies[1]. (R) -TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2735015-59-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-ttbk1-in-1.html

Purity

98.93

Solubility

Ethanol : 33.33 mg/mL (ultrasonic; adjust pH to 3 with HCl)

Smiles

O[C@](C)(CC)C#CC1=CC2=C(C=CN2C3=CC(OC)=NC(N)=N3)C=N1

Molecular Formula

C18H19N5O2

Molecular Weight

337.38

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Halkina T, et, al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64 (9) :6358-6380.