NB-598

NB-598 is a potent and competitive inhibitor of squalene epoxidase (SE), and suppresses triglyceride biosynthesis through the farnesol pathway. NB-598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[131060-14-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nb-598.html

Concentration

10mM

Purity

98.69

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCN(C/C=C/C#CC(C)(C)C)CC1=CC=CC(OCC2=CC(C3=CSC=C3)=CS2)=C1

Molecular Formula

C27H31NOS2

Molecular Weight

449.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149 (10) :5136-45.|[2]Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46 (2) :297-305.|[3]Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168 (1) :45-51.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Adv Sci (Weinh) . 2023 Sep;10 (27) :e2206878.|Antioxidants (Basel) . 2024 Jun 13;13 (6) :722.|Arch Pharm (Weinheim) . 2025 Feb;358 (2) :e2400807.|Cancer Lett. 2025 May 23:217810.|Cancer Res. 2022 Sep 2;82 (17) :3032-3044.|Cell Chem Biol. 2021 Jun 17;28 (6) :866-875.e5.|Cell Metab. 2020 Apr 7;31 (4) :862-877.e14.|Genome Biol. 2016 Jun 29;17 (1) :140. |J Steroid Biochem Mol Biol. 2015 Aug;152:34-44.|Sci China Life Sci. 2022 Feb;65 (2) :341-361.|Cell Death Dis. 2021 May 13;12 (5) :482.|Cell Rep. 2020 Aug 4;32 (5) :107944.|Nat Chem Biol. 2016 Jul;12 (7) :497-503. |University of Toronto. Department of Medical Biophysics