Substance P [D-Arg1, D-Trp5, 7, 9, Leu11] peptide
Substance P [D-Arg1, D-Trp5, 7, 9, Leu11] peptide
Product Specifications
Source
Synthetic
Field of Research
Signal Transduction
Purity
> 95%
Form
Lyophilized powder
Molecular Weight
1555.91
Storage Conditions
Shipped at 4°C. Store at -20°C for one year.
Notes
For research use only.
Applications Notes
This substance P analog is a very potent broad-spectrum neuropeptide inhibitor for small cell lung cancer (SCLC) cell growth in vitro (IC50 = 5 μM) . Moreover it potently inhibited signal transduction pathways in vitro and significantly delayed the growth of an SCLC xenograft in vivo. It could therefore be of therapeutic value in SCLC.
AA Sequence
D-Arg-Pro-Lys-Pro-D-Trp-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
Available Sizes
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