Mouse Ac-[Cys (Acm) -EGF amide peptide
Mouse Ac-[Cys (Acm) -EGF amide peptide
Product Specifications
Source
Synthetic
Field of Research
Cancer Biology
Purity
> 95%
Form
Lyophilized powder
Molecular Weight
1255.45
Storage Conditions
Shipped at 4°C. Store at -20°C for one year.
Notes
For research use only.
Applications Notes
This EGF-derived peptide is known as a laminin antagonist. It blocks the stimulatory effects of laminin in cell motility and chick angiogenesis. This peptide binds to a breast cancer- and endothelial cell-associated receptor, which is specific for residues 925 to 933 of the laminin B1 chain. The IC50 values for displacement of laminin are in the range of 1-3 nM, depending on the cells. This peptide has an antimetastatic potential.
AA Sequence
Ac-Cys (Acm) -Val-Ile-Gly-Tyr-Ser-Gly-Asp-Arg-Cys (Acm) -NH2
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