Beta-Amyloid-Protein [Pyr11] peptide

[Pyr11]-Beta-Amyloid-Protein (11-40), the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr11) -amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.