Apovincaminic acid (hydrochloride salt)

Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP) . Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2].

Product Specifications

CAS Number

[72296-47-0]

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/apovincaminic-acid-hydrochloride-salt.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC[C@@]12[C@@]3([H])C4=C(CCN3CCC2)C5=CC=CC=C5N4C(C(O)=O)=C1.[H]Cl

Molecular Formula

C20H23ClN2O2

Molecular Weight

358.86

References & Citations

[1]Nyakas C, et, al. Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model. CNS Neurosci Ther. Summer 2009;15 (2) :89-99.|[2]Pudleiner P, et, al. Study on the absorption of vinpocetine and apovincaminic acid. Eur J Drug Metab Pharmacokinet. Oct-Dec 1993;18 (4) :317-21.|[3]Wang M, et, al. Simultaneous Determination of Vinpocetine and its Major Active Metabolite Apovincaminic Acid in Rats by UPLC-MS/MS and its Application to the Brain Tissue Distribution Study. J Chromatogr Sci. 2018 Mar 1;56 (3) :225-232.