Thrombin Receptor Agonist peptide

Product Specifications

Product Name Alternative

Thrombin Receptor Activator Peptide 14, PAR-1 (1-14) (human), Proteinase Activated Receptor 1 (1-14) (human), Thrombin Receptor (1-14) (human), Coagulation Factor II Receptor (1-14) (human)

Source

Synthetic

Field of Research

Pharmacology & Drug Discovery

Purity

> 95%

Form

Lyophilized powder

Molecular Weight

1739.96

Storage Conditions

Shipped at 4°C. Store at -20°C for one year.

Notes

For research use only.

Applications Notes

Cloning and expression of a functional human thrombin receptor have revealed a protein with seven transmembrane domains and a large extracellular amino-terminal extension. Thrombin cleaves within this extension, thereby creating a new receptor amino-terminus that functions as a tethered ligand and activates the receptor. A 14-amino acid peptide mimicking this new amino-terminus has been found to be a potent thrombin receptor activator as well as an effective agonist for platelet activation.