Opipramol

Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) . Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) [1][2].

Product Specifications

CAS Number

[315-72-0]

Product Name Alternative

Ensidon; G-33040

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/opipramol.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCN1CCN(CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1

Molecular Formula

C23H29N3O

Molecular Weight

363.50

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]H J Möller, et al. Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group. J Clin Psychopharmacol. 2001 Feb;21 (1) :59-65. |[2]T S Rao, et al. Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo. Neuropharmacology. 1990 Dec;29 (12) :1191-7.