(E) -3,4,5-Trimethoxycinnamic acid

(E) -3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E) -3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E) -3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E) -3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E) -3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy[1][2][3].

Product Specifications

CAS Number

[20329-98-0]

Product Name Alternative

TMCA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; GABA Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-3-4-5-trimethoxycinnamic-acid.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/C1=CC(OC)=C(OC)C(OC)=C1

Molecular Formula

C12H14O5

Molecular Weight

238.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhao Z, et al. Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives. Eur J Med Chem. 2019 Jul 1;173:213-227.|[2]Chen CY, et al. 3,4,5-Trimethoxycinnamic acid, one of the constituents of Polygalae Radix exerts anti-seizure effects by modulating GABAAergic systems in mice. J Pharmacol Sci. 2016 May;131 (1) :1-5. |[3]Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36 (10) :1244-51.