AF-353
Product Specifications
UNSPSC Description
AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].
Target Antigen
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AF-353.html
Solubility
DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CC(C)C1=C(OC2=CN=C(N)N=C2N)C=C(I)C(OC)=C1
Molecular Weight
400.21
References & Citations
[1]Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398.|[2]Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14483/AF-353-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14483/AF-353-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
865305-30-2
Available Sizes
Curated Selection
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