HY-078020
HY-078020 (compound III-4) is a selective, orally active antagonist for histamine H1 receptor with an IC50 of 24.12 nM. HY-078020 exhibits an anti-inflammatory effect in allergic diseases[1].
Product Specifications
CAS Number
[2756222-90-7]
UNSPSC
12352005
Target
Histamine Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hy-078020.html
Purity
98.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC(C=C1)=CC(CCC2=C/3N=CC=C2)=C1C3=C4CCN(CCCC5=CC(C(C)(C(O)=O)C)=CC=C5)CC/4
Molecular Formula
C32H35ClN2O2
Molecular Weight
515.09
References & Citations
[1]Chu Z, et al., Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases. Eur J Med Chem. 2024 Feb 3;268:116197.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor; mAChR3
Available Sizes
Curated Selection
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