Recombinant LCK Protein

<strong>Recombinant LCK Protein</strong>_x000D_ <strong>Catalog number:</strong> B2017661_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 59.3 kDa_x000D_ <strong>Supplied as:</strong> SOLUTION_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> LCK Proto-Oncogene, Src Family Tyrosine Kinase_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Jullien P, Bougeret C, Camoin L, Bodeus M, Durand H, Disanto JP, Fischer S, Benarous R. Tyr394 and Tyr505 are autophosphorylated in recombinant Lck protein-tyrosine kinase expressed in Escherichia coli Eur J Biochem. 1994 Sep 1;224(2):589-96._x000D_ 2: Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean-Tate K, McCrae K, Joehlin-Price A, Rose PG, Lathia J, Gong Z, Reizes O. LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer J Ovarian Res. 2023 Jun 27;16(1):122._x000D_ 3: Kabouridis PS, Magee AI, Ley SC. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes EMBO J. 1997 Aug 15;16(16):4983-98._x000D_ 4: Torigoe T, Millan JA, Chan KW, Taichman R, Brian AA, Reed JC, Tachman R [corrected to Taichman R]. Protein tyrosine kinase p56-Lck regulates lymphocyte function-associated 1 adhesion molecule expression, granule exocytosis, and cytolytic effector function in a cloned T cell J Exp Med. 1994 Sep 1;180(3):1115-27._x000D_ 5: Pathan NI, Geahlen RL, Harrison ML. The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2 J Biol Chem. 1996 Nov 1;271(44):27517-23._x000D_ 6: Lee-Fruman KK, Collins TL, Burakoff SJ. Role of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation J Biol Chem. 1996 Oct 4;271(40):25003-10._x000D_ 7: Hardwick JS, Sefton BM. Activation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394 Proc Natl Acad Sci U S A. 1995 May 9;92(10):4527-31._x000D_ 8: Baur AS, Sass G, Laffert B, Willbold D, Cheng-Mayer C, Peterlin BM. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase Immunity. 1997 Mar;6(3):283-91._x000D_ 9: Kjellen P, Amdjadi K, Lund TC, Medveczky PG, Sefton BM. The herpesvirus saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro Virology. 2002 Jun 5;297(2):281-8._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33864023">10: Hu XX, Zhang AJ, Pan WW, Xin QL, Chen JY, Zhang LL, Chang Y, Wu YJ, Wei W. An IgD-Fc-Ig fusion protein restrains the activation of T and B cells by inhibiting IgD-IgDR-Lck signaling in rheumatoid arthritis Acta Pharmacol Sin. 2022 Feb;43(2):387-400. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant LCK Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>