BAY-707

BAY-707, a chemical probe, is a substrate-competitive, highly potent and selective inhibitor of MTH1 (NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy[1].

Product Specifications

CAS Number

[2109805-96-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bay-707.html

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC)C(N1)=CC2=C1N=CC=C2N3CCOC[C@@H]3C

Molecular Formula

C15H20N4O2

Molecular Weight

288.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Ellermann M, et al. Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.ACS Chem Biol. 2017 Aug 18;12 (8) :1986-1992.