Human Siglec-7 Protein, Fc Tag
Human Siglec-7, Fc (L118A, G120A, E201A) Tag is expressed from human 293 cells (HEK293) . It contains AA Gln 19 - Leu 353 (Accession # Q9Y286-1) .
Product Specifications
UniProt
Q9Y286
Expression Region
Gln 19 - Leu 353
Reactivity
Human
Conjugation
Unconjugated
Tag
C-Fc (A3)
Field of Research
Immunology & Inflammation
Endotoxin
0.01 EU per μg
Purity
95%
Form
Powder
Molecular Weight
63.3 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
This protein carries a Fc (L118A, G120A, E201A) tag at the C-terminus. The protein has a calculated MW of 63.3 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L118A, G120A, E201A /EU number: L235A/G237A/E318A) in human immunoglobulin G1 (hIgG1) Fc strongly reduce binding of the Fc mutant to cell expressed FcγRs, resulting in an almost 4-fold reduction in ADCC compared to that of wild type human IgG1.
NCBI Accession Number
Q9Y286
Preservative
25 mM MES, 150 mM NaCl, pH 7.4
Available Sizes
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