KG-548

KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].

Product Specifications

CAS Number

[175205-09-1]

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kg-548.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C1=CC(C(F)(F)F)=CC(C2=NN=NN2)=C1)(F)F

Molecular Formula

C9H4F6N4

Molecular Weight

282.15

Precautions

H228, H315, H319

References & Citations

[1]Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8 (3) :626-35. |[2]Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27 (6) :735-742.