(24S,25) -Epoxycholesterol

24S,25-Epoxycholesterol is an agonist for Liver X Receptor (LXR) . 24S,25-Epoxycholesterol exhibits properties in regulating the cholesterol efflux[1], inhibiting tumor growth against gastric cancer and glioblastoma[2][3] and inducing apoptosis in BMMC cells[5].

Product Specifications

CAS Number

[77058-74-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

LXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/24s-25-epoxycholesterol.html

Purity

98.10

Solubility

Ethanol : 16 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@H]3C(C)(O3)C)([H])[C@@]4([H])[C@@](CC1)([H])[C@@]5(C(C[C@H](CC5)O)=CC4)C

Molecular Formula

C27H44O2

Molecular Weight

400.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Beyea MM, et al., Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24 (S),25-epoxycholesterol. J Biol Chem. 2007 Feb 23;282 (8) :5207-16.|[2]Guo F, et al., Upregulation of 24 (R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells. Biochem Biophys Res Commun. 2018 Oct 12;504 (4) :892-898.|[3]Nguyen TP, et al., Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24 (S),25-epoxycholesterol production. Cell Chem Biol. 2023 Feb 16;30 (2) :214-229.e18.|[4]Theofilopoulos S, et al., 24 (S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo. J Biol Chem. 2019 Mar 15;294 (11) :4169-4176.|[5]Fukunaga M, et al., Mast cell death induced by 24 (S),25-epoxycholesterol. Exp Cell Res. 2010 Nov 15;316 (19) :3272-81.