Ombitasvir

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a.

Product Specifications

CAS Number

[1258226-87-7]

Product Name Alternative

ABT-267

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Ombitasvir.html

Purity

99.79

Solubility

DMSO : ≥ 33 mg/mL

Smiles

CC(C)(C)C(C=C1)=CC=C1N2[C@H](C3=CC=C(NC([C@H]4N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC4)=O)C=C3)CC[C@H]2C5=CC=C(NC([C@@H]6CCCN6C([C@@H](NC(OC)=O)C(C)C)=O)=O)C=C5

Molecular Formula

C50H67N7O8

Molecular Weight

894.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Krishnan P, et al. In vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis C virus NS5A. Antimicrob Agents Chemother. 2015 Feb;59 (2) :979-87|[2]DeGoey DA, et al. Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A. J Med Chem. 2014 Mar 13;57 (5) :2047-57