Venetoclax
Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].
Product Specifications
CAS Number
1257044-40-8
Product Name Alternative
ABT-199; GDC-0199; RG7601
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H361, H373
Target
Autophagy; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ABT-199.html
Purity
99.96
Solubility
DMSO : 77.5 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL
Smiles
O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN=C(NC=C8)C8=C7
Molecular Formula
C45H50ClN7O7S
Molecular Weight
868.44
Precautions
H302, H315, H319, H361, H373
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Bcl-2; Bcl-W; Bcl-xL
Available Sizes
Frequently Asked Questions
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