Wychimicin C

Wychimicin C is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin C shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) [1][2].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/wychimicin-c.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C(C)=C(C=C1)Cl)C(N[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@]([H])(C/C=C/C3[C@@]4([C@]5([C@]([H])(C=C3CC)[C@H]([C@H](C[C@@H]5C)O)O)[H])C)/C(C)=C/[C@H]6[C@]7(C[C@@H](C=C6)C)C(O)=C(C(O7)=O)C4=O)C)=O

Molecular Formula

C46H58ClNO11

Molecular Weight

836.41

References & Citations

[1]Kimura T, et al. Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4. J Antibiot (Tokyo) . 2022 Oct;75 (10) :535-541. |[2]Hatano M, et al. Actinocrispum wychmicini gen. nov., sp. nov., a novel member of the family Pseudonocardiaceae, isolated from soil. Int J Syst Evol Microbiol. 2016 Nov;66 (11) :4779-4784.