FH535
FH535 is an inhibitor of Wnt/β-catenin and PPAR with anti-tumor activities[1].
Product Specifications
CAS Number
108409-83-2
UNSPSC
12352005
Hazard Statement
H302, H318
Target
PPAR; Wnt; β-catenin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fh535.html
Purity
99.95
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(Cl)=CC=C1Cl)(NC2=CC=C([N+]([O-])=O)C=C2C)=O
Molecular Formula
C13H10Cl2N2O4S
Molecular Weight
361.20
Precautions
H302, H318
References & Citations
[1]Handeli S, et al. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol Cancer Ther. 2008 Mar;7 (3) :521-9.|[2]Wu MY, et al. FH535 inhibited metastasis and growth of pancreatic cancer cells. Onco Targets Ther. 2015 Jul 6;8:1651-70.|[3]Liu L, et al. FH535, a β-catenin pathway inhibitor, represses pancreatic cancer xenograft growth and angiogenesis. Oncotarget. 2016 Jul 26;7 (30) :47145-47162.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPAR
Available Sizes
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