Psoralidin

Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR) -induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties[1]. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation[2].

Product Specifications

CAS Number

[18642-23-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; COX; Lipoxygenase; Notch; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Psoralidin.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C/C(C)=C\CC1=C(C=C2OC(C3=C(C2=C1)OC4=C3C=CC(O)=C4)=O)O

Molecular Formula

C20H16O5

Molecular Weight

336.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang HJ, et al. Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR) -induced pulmonary inflammation.Biochem Pharmacol. 2011 Sep 1;82 (5) :524-34.|[2]Suman S, et al. Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells.Br J Cancer. 2013 Nov 12;109 (10) :2587-96.