Adrenochrome

Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research[1][2][3].

Product Specifications

CAS Number

[54-06-8]

Product Name Alternative

Adraxone

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/adrenochrome.html

Concentration

10mM

Purity

99.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C2C(CN(C2=CC1=O)C)O

Molecular Formula

C9H9NO3

Molecular Weight

179.17

Precautions

H315, H319, H320

References & Citations

[1]M Karmazyn, , et al. Adrenochrome-induced coronary artery constriction in the rat heart. J Pharmacol Exp Ther. 1981 Oct;219 (1) :225-30.|[2] S Takeo, et al. Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. J Pharmacol Exp Ther. 1980 Sep;214 (3) :688-93.|[3]Koji Ueda, et al. Catecholamine oxidation-mediated transcriptional inhibition in Mn neurotoxicity. J Toxicol Sci. 2020;45 (10) :619-624.