PF-670462 (dihydrochloride)

PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC50s of 7.7 nM and 14 nM, respectively.

Product Specifications

CAS Number

[950912-80-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pf-670462-dihydrochloride.html

Purity

99.96

Solubility

DMSO : ≥ 32 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCCC4)=N1.[H]Cl.[H]Cl

Molecular Formula

C19H22Cl2FN5

Molecular Weight

410.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Badura L, et al. An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. J Pharmacol Exp Ther. 2007 Aug;322 (2) :730-8. Epub 2007 May 14.|[2]Cheong JK, et al. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/? and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene. 2011 Jun 2;30 (22) :2558-69.|[3]Kennaway DJ, et al. Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms. Mol Cell Biochem. 2015 Jan;398 (1-2) :195-206.