E3 ligase Ligand 32
E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743) [1].
Product Specifications
CAS Number
[2300099-98-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-32.html
Purity
99.96
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC(=O)C(CC1)N2C3=C(C=C(Br)C=C3)N(C)C2=O
Molecular Formula
C13H12BrN3O3
Molecular Weight
338.16
Precautions
H302, H315, H319
References & Citations
[1]Nan Ji, et al. Smarca degraders and uses thereof. Worldwide applications 2020 US WO
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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