E3 ligase Ligand 32

E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743) [1].

Product Specifications

CAS Number

[2300099-98-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-32.html

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1NC(=O)C(CC1)N2C3=C(C=C(Br)C=C3)N(C)C2=O

Molecular Formula

C13H12BrN3O3

Molecular Weight

338.16

Precautions

H302, H315, H319

References & Citations

[1]Nan Ji, et al. Smarca degraders and uses thereof. Worldwide applications 2020 US WO

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Von Hippel-Lindau (VHL)

Available Sizes

Curated Selection

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