PKI (5-24), amide
PKI (5-24), amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependent protein kinase. PKI (5-24), amide is a potent cAMP-dependent protein kinase (PKA) (PKA) inhibitor with a Ki of 2.3 nM[1].
Product Specifications
CAS Number
100891-36-9
Product Name Alternative
IP20-amide
UNSPSC
12352209
Target
PKA
Type
Peptides
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pki-5-24-amide.html
Solubility
10 mM in DMSO
Smiles
OC(C[C@@H](C(N)=O)NC([C@H](CC1=CN=CN1)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(CNC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CO)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](C)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](N)[C@H](O)C)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C94H149N33O30
Molecular Weight
2221.39
References & Citations
[1]D B Glass, et al. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J Biol Chem. 1989 May 25;264 (15) :8802-10.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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