G150
Product Specifications
UNSPSC Description
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC50 of 10.2 nM. G150 represses dsDNA-triggered interferon expression, and G150 can be used for the research of inflammatory[1].
Target Antigen
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/g150.html
Purity
99.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=CC=C(C2=C3C(NC4=C3CN(C(CO)=O)CC4)=C(Cl)C(Cl)=C2)C=N1
Molecular Weight
391.25
References & Citations
[1]Lama L, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21;10(1):2261.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128583/G150-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128583/G150-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2369751-30-2
Available Sizes
Curated Selection
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