Indole-3-carboxylic acid

Indole-3-carboxylic acid is an orally active urinary indolic tryptophan metabolite. Indole-3-carboxylic acid is a mediator of priming against Plectosphaerella cucumerina. Indole-3-carboxylic acid enhances the anti-colorectal cancer potency of Doxorubicin (HY-15142A) by inducing cell senescence. Indole-3-carboxylic acid can be used in liver disease research[1][2][3][4].

Product Specifications

CAS Number

[771-50-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Indole-3-carboxylic_acid.html

Concentration

10mM

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CNC2=CC=CC=C12

Molecular Formula

C9H7NO2

Molecular Weight

161.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Byrd DJ, et al. The analysis of indolic tryptophan metabolites in human urine. Thin-layer chromatography and in situ quantitation. J Chromatogr. 1974 Jul 17;94 (0) :85-106.|[2]HARTMANN F, et al. [Indolepatterns in the urine of liver patients]. Klin Wochenschr. 1962 Jul 15;40:721-9.|[3]Gamir J, et al. Identification of indole-3-carboxylic acid as mediator of priming against Plectosphaerella cucumerina. Plant Physiol Biochem. 2012 Dec;61:169-79.|[4]ZHOU Y A O, et al. INDOLE-3-CARBOXYLIC ACID ENHANCED ANTI-CANCER POTENCY OF DOXORUBICIN VIA INDUCTION OF CELLULAR SENESCENCE IN COLORECTAL CELLS. Acta Poloniae Pharmaceutica, 2024, 81 (1) .