Canrenone

Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.

Product Specifications

CAS Number

[976-71-6]

Product Name Alternative

Aldadiene; SC9376

UNSPSC

12352005

Hazard Statement

H351, H411

Target

Endogenous Metabolite; Mineralocorticoid Receptor

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Canrenone.html

Purity

99.83

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3(CCC(O3)=O)CC[C@@]1([H])[C@]4([H])C=CC5=CC(CC[C@]5(C)[C@@]4([H])CC2)=O

Molecular Formula

C22H28O3

Molecular Weight

340.46

Precautions

H351, H411

References & Citations

[1]Erbler HC, et al. On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1973;277 (2) :139-49.|[2]Caligiuri A, et al. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology. 2003 Feb;124 (2) :504-20.|[3]Erbler HC, et al. Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Acta Endocrinol (Copenh) . 1979 Jan;90 (1) :147-56.