SX 011

SX 011 is a p38 inhibitor with IC50s of 9 nM and 90 nM against p38α and p38β, respectively. SX 011 also inhibits JNK-2 with an IC50 of 100 nM. SX-011 is orally bioavailable[1].

Product Specifications

CAS Number

[309913-42-6]

UNSPSC

12352005

Target

JNK; p38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sx-011.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3CCC(CC4=CC=C(F)C=C4)CC3)=O)C(Cl)=C2)=O

Molecular Formula

C26H27ClFN3O3

Molecular Weight

483.96

References & Citations

[1]Lee MR, et al. MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alpha protein. Curr Med Chem. 2005;12 (25) :2979-94.|[2]Hynes J Jr, et al. Small molecule p38 inhibitors: novel structural features and advances from 2002-2005. Curr Top Med Chem. 2005;5 (10) :967-85.