Zaltidine

Zaltidine dihydrochloride (CP-5736 dihydrochloride) is a highly specific H2 receptor antagonist with antisecretion activity. Zaltidine dihydrochloride reduces the stimulant effect of histamine on gastric acid secretion by binding to histamine H2 receptors on gastric parietal cells, thus reducing gastric acid production. Zaltidine dihydrochloride can be used in the study of gastric acid-related diseases such as duodenal ulcers[1].

Product Specifications

CAS Number

[85604-00-8]

Product Name Alternative

CP-57361

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/zaltidine.html

Purity

99.49

Solubility

10 mM in DMSO|H2O : 7.69 mg/mL (ultrasonic)

Smiles

NC(NC1=NC(C2=CN=C(C)N2)=CS1)=N

Molecular Formula

C8H10N6S

Molecular Weight

222.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Laferla G, Buchanan N, Hearns J, The antisecretory effects of zaltidine, a novel long-acting H2-receptor antagonist, in healthy volunteers and in subjects with a past history of duodenal ulcer. Br J Clin Pharmacol. 1986 Oct;22 (4) :395-9.|[2]Farup PG. Zaltidine: an effective but hepatotoxic H2-receptor antagonist. Scand J Gastroenterol. 1988 Aug;23 (6) :655-8.