UR-AK49

UR-AK49 (compound 11) is a human histamine H1 and H2 receptor agonist. UR-AK49 has an EC50 of 23 nM in a GTPase assay with hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 can be used in neuro-related research[1].

Product Specifications

CAS Number

[902154-32-9]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ur-ak49.html

Smiles

O=C(CCC1CCCCC1)NC(NCCCC2=CN=CN2)=N

Molecular Formula

C16H27N5O

Molecular Weight

305.42

References & Citations

[1]Xie SX, et al. N1- (3-cyclohexylbutanoyl) -N2-[3- (1H-imidazol-4-yl) propyl]guanidine (UR-AK57), a potent partial agonist for the human histamine H1- and H2-receptors. J Pharmacol Exp Ther. 2006 Jun;317 (3) :1262-8.