COX-2-IN-6

COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC50 of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM[1].

Product Specifications

CAS Number

[2756347-91-6]

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cox-2-in-6.html

Purity

98.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCOC1=NC(OCC(C)(O)C)=C(C=C1CO)C2=CC=C(C=C2)S(C)(=O)=O

Molecular Formula

C20H27NO6S

Molecular Weight

409.50

References & Citations

[1]Zhang Z, et al. Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer. J Med Chem. 2021 Aug 12;64 (15) :11570-11596.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-2

Available Sizes

Curated Selection

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