COX-2-IN-6
COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC50 of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM[1].
Product Specifications
CAS Number
[2756347-91-6]
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cox-2-in-6.html
Purity
98.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCOC1=NC(OCC(C)(O)C)=C(C=C1CO)C2=CC=C(C=C2)S(C)(=O)=O
Molecular Formula
C20H27NO6S
Molecular Weight
409.50
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
Available Sizes
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